Properties of submicron sized vaterite particles for incorporation of proteins

The ability of proteins and glycoproteins loading was compared for submicron vaterite particles obtained in an ethylene glycol-containing medium and micron vaterite particles prepared in a Tris buffer medium. Various proteins were encapsulated into submicron vaterite particles by coprecipitation and adsorption, and the protein content and enzyme activity preservation were assessed. The behavior of submicron vaterite particles with adsorbed catalase was investigated under conditions simulating passage through the human gastrointestinal tract, including the presence of proteolytic enzymes.