载脂蛋白E
2型糖尿病
内科学
基因型
医学
等位基因
血脂
糖尿病
人口
2型糖尿病
逻辑回归
内分泌学
胆固醇
遗传学
生物
基因
环境卫生
疾病
作者
Yali Zeng,Shuang Wen,Lijun Huan,Liang Xiong,Botao Zhong,Pengyun Wang
出处
期刊:PeerJ
[PeerJ]
日期:2023-04-24
卷期号:11: e15226-e15226
摘要
Background Apolipoprotein E ( ApoE ) is involved in lipid transformation and metabolism. Although some studies have examined the association between ApoE polymorphisms and the risk of type 2 diabetes mellitus (T2DM), the findings differ depending on the location and population. Methods A total of 1,738 participants, including 743 patients with T2DM and 995 controls without T2DM, were enrolled from central China, and ApoE polymorphisms, 388T > C ( rs429358 ) and 526C > T ( rs7412 ), were genotyped. The association between ApoE alleles and T2DM and blood lipid levels was analyzed. Logistic regression analysis was performed to evaluate the interactions between ApoE polymorphisms and various factors, such as age, sex, and prevalence of hypertension in patients with T2DM. Results The genotype ɛ 3/ ɛ 4 and ɛ 4 alleles of ApoE were associated with T2DM risk in the Chinese Han population in central China. Moreover, in patients with T2DM, participants in the E4 ( ɛ 3/ ɛ 4, ɛ 4/ ɛ 4) group had significantly higher lipid profiles than those in the E3 ( ɛ 3/ ɛ 3) group, whereas participants in the E2 group ( ɛ 2/ ɛ 2, ɛ 2/ ɛ 3) showed lower total cholesterol, low-density lipoprotein cholesterol, and ApoE-A1 levels than those in the E3 ( ɛ 3/ ɛ 3) group. The results from the current study may help in understanding ApoE polymorphisms and lipid profiles in the Chinese Han population.
科研通智能强力驱动
Strongly Powered by AbleSci AI