Visible‐Light‐Induced Cascade Phosphinoylation/Cyclization of Phenacylmalononitriles with Secondary H‐phosphine Oxides

Abstract The visible‐light‐induced synthesis of 5‐phosphoryl‐functionalized pyrroles has been established by eosin Y catalysis, and different electron‐donating or electron‐withdrawing group substituted secondary H ‐phosphine oxides and phenacylmalononitriles showed good reactivity toward the reaction, affording the cascade phosphinoylation/cyclization products in 82–98% yields via P−C/C−N annulation. Step‐by‐step control experiments and 31 P NMR tracking experiments were further performed to gain the insights of the plausible reaction mechanism and kinetic reaction process. This reaction may have implications for the construction of C( sp 2 )−P bonds in organophosphorus chemistry. magnified image