H2BC9 lactylation modulates esophageal squamous cell carcinoma progression via the Wnt/β-catenin signaling pathway

Our study reveals a novel regulatory axis in which H2BC9 K44 lactylation activates Wnt7b transcription and downstream Wnt/β-catenin signaling, driving ESCC progression. Targeting H2BC9 lactylation may offer a promising therapeutic strategy to overcome tumor growth and immune evasion in ESCC.