病毒
病毒学
细胞
病毒复制
传输(电信)
传染性
细胞培养
作者
Kyle D. Pedro,Andrew J. Henderson,Luis M. Agosto
标识
DOI:10.1016/j.virusres.2019.03.014
摘要
HIV-1 spreads through both the release of cell-free particles and by cell-to-cell transmission. Mounting evidence indicates that cell-to-cell transmission is more efficient than cell-free transmission of particles and likely influences the pathogenesis of HIV-1 infection. This mode of viral transmission also influences the generation and maintenance of the latent reservoir, which represents the main obstacle for curing the infection. In this review we will discuss general cell contact-dependent mechanisms that HIV-1 utilizes for its spread and the evidence pointing to cell-to-cell transmission as a mechanism for the establishment and maintenance of latent infection.
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