SUN-010 REDUCING 'PODOCYTE DENSITY' MIGHT PREDICTS FSGS BUT NOT MCD IN CASE OF NEPHROTIC SYNDROME

Focal segmental glomerulosclerosis (FSGS) is an aggressive disease often leading to renal failure. It might be difficult to distinguish FSGS from minimal change disease (MCD) when renal biopsies from patients with nephrotic syndrome do not indicate sclerotic lesions. Based on the rat model study, reducing podocyte density (average podocyte number per glomerular volume), which suggests relative podocyte depletion, could be seen in FSGS, but not MCD. Here, we compared the following histological parameters of FSGS and MCD in renal biopsy specimens of nephrotic patients.