Hypoxia-Inducible Factor-1 and p53: Friends, Acquaintances, or Strangers?

In this issue of Clinical Cancer Research , Sumiyoshi et al. ([1][1]) report on overexpression of hypoxia-inducible factor-1α (HIF-1α) and p53. HIF-1 and p53 are two of the most highly studied transcription factors; therefore, it is perhaps not surprising that reports of interactions between them