The relationship between apoptosis,atresia folliculi and missed abortion mediated by Fas/FasL system

Fas/FasL were two kinds of transmembrane protein on the cell surface.The current study showed that FasL was the death factor and Fas was its receptor.When the FasL of a cell combined with the Fas of another,they could lead that the cell which expressed Fas died.Fas was named Apo-1,meaning CD95.Fas gene was located on human q23 of the chromosome 10 and the gene length was about 25 Kb.FasL gene was located on human q23 of the chromosome 1 and the gene length was about 8Kb.The Fas/FasL system was closely related to Physiological process of follicular atresia,autoimmune diseases,tumors and graft tolerance.Recently the incidence of missed abortion related to apoptosis has been attended by people and the Fas/FasL system is important in promoting apoptosis.