光热治疗
黑色素瘤
免疫疗法
免疫系统
癌症研究
转移
医学
免疫原性细胞死亡
肿瘤微环境
癌症
癌症免疫疗法
免疫学
纳米技术
材料科学
内科学
作者
Jiyuan Zhang,Weidong Gao,Jiao Lin,Shuang Xu,Lijun Zhang,Xulin Lu,Xin Luan,Jianqing Peng,Yi Chen
标识
DOI:10.1080/1061186x.2023.2216402
摘要
Melanoma is the most aggressive form of skin cancer and there is a need for the development of effective anti-melanoma therapies as it shows high metastatic ability and low response rate. In addition, it has been identified that traditional phototherapy could trigger immunogenic cell death (ICD) to activate antitumor immune response, which could not only effectively arrest primary tumour growth, but also exhibit superior effects in terms of anti-metastasis, anti-recurrence for metastatic melanoma treatment. However, the limited tumour accumulation of photosensitizers/photothermal agents and immunosuppressive tumour microenvironment severely weaken the immune effects. The application of nanotechnology facilitates a higher accumulation of photosensitizers/photothermal agents at the tumour site, which can thus improve the antitumor effects of photo-immunotherapy (PIT). In this review, we summarise the basic principles of nanotechnology-based PIT and highlight novel nanotechnologies that are expected to enhance the antitumor immune response for improved therapeutic efficacy.
科研通智能强力驱动
Strongly Powered by AbleSci AI