Thrombogenicity assessment of surface-modified flow diverters: the impact of different surface modification strategies on thrombin generation in an acute in vitro test

Generally, surface modification resulted in lower thrombogenicity, as assessed by peak thrombin concentration and TTP, when compared with the unmodified version of the device. The device with an active heparin drug coating was significantly different from other surface modifications and plasma with respect to peak thrombin and TTP, though the implications of this should be investigated through future in vitro and in vivo studies.