Palladium/norbornene cooperative catalysis triple functionalization: carbamoylation/double-annulation of (hetero)aryl iodides

A novel Pd/NBE-catalyzed intermolecular dehydrobicyclization of heteroaryl iodides for the synthesis of polycyclic nitrogen-containing heterocycles is reported. In this work, the N-protected aryl carbamoyl chloride serves as a source of acylation. The products resulting from the direct C-H functionalization of heteroaryl iodides are smoothly obtained without catalyst poisoning by heteroatoms.