纳米孔
拉曼散射
材料科学
纳米技术
拉曼光谱
电场
腺苷
三磷酸腺苷
光电子学
化学
光学
生物化学
物理
量子力学
作者
Hai-Ling Liu,Saud Asif Ahmed,Qiucen Jiang,Qi Shen,Kan Zhan,Kang Wang
出处
期刊:ACS Sensors
[American Chemical Society]
日期:2023-03-15
卷期号:8 (3): 1280-1286
被引量:5
标识
DOI:10.1021/acssensors.2c02759
摘要
A reliable, rapid, cost-effective, and simple method for the detection of biomolecules would greatly promote the research of analytical detection of single molecules. A nanopore-based analytical technique is promising for detecting biomolecules. Conventional electrochemical nanopores cannot distinguish biomolecules precisely because of their fast translocation speed and limited electrochemical information. Therefore, it is highly desirable to develop electrochemical surface-enhanced Raman scattering (SERS) nanopores to obtain multidimensional information. Herein, we designed and fabricated gold nanotriangle (AuNT)-assembled porous structures at the tip of a glass capillary using dithiol adenosine triphosphate (ATP) aptamers as cross-linking molecules. The AuNTs exhibited an edge length of 57.3 ± 6.2 nm and thickness of about 15 nm. The gold nanoporous structure (GPS) showed a strong ion rectification even at a high concentration of electrolyte (2 M) and a high SERS activity. Based on these designed structures, SERS and electrochemistry techniques were combined to control the rapid movement of ATP to the vicinity of the GPS by an applied potential of +1 V, where ATP was concentrated by ATP aptamers and the molecular signals were amplified by SERS. As a result, the GPS successfully detected ATP at a concentration as low as 10-7 M.
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