Enantioselective synthesis of α-chiral sulfonates through palladium-catalyzed Tsuji–Trost sulfonylation with sulfur dioxide

We present a novel palladium-catalyzed asymmetric Tsuji–Trost reaction featuring sulfur dioxide insertion through a palladium-sulfonyl intermediate. This method yields α-chiral sulfonates with high efficiency and excellent enantioselectivities.