A multi-objective based radiomics feature selection method for response prediction following radiotherapy

Objective.Radiomics contains a large amount of mineable information extracted from medical images, which has important significance in treatment response prediction for personalized treatment. Radiomics analyses generally involve high dimensions and redundant features, feature selection is essential for construction of prediction models.Approach.We proposed a novel multi-objective based radiomics feature selection method (MRMOPSO), where the number of features, sensitivity, and specificity are jointly considered as optimization objectives in feature selection. The MRMOPSO innovated in the following three aspects: (1) Fisher score to initialize the population to speed up the convergence; (2) Min-redundancy particle generation operations to reduce the redundancy between radiomics features, a truncation strategy was introduced to further reduce the number of features effectively; (3) Particle selection operations guided by elitism strategies to improve local search ability of the algorithm. We evaluated the effectiveness of the MRMOPSO by using a multi-institution oropharyngeal cancer dataset from The Cancer Imaging Archive. 357 patients were used for model training and cross validation, an additional 64 patients were used for evaluation.Main results.The area under the curve (AUC) of our method achieved AUCs of 0.82 and 0.84 for cross validation and independent dataset, respectively. Compared with classical feature selection methods, the AUC of MRMOPSO is significantly higher than the Lasso (AUC = 0.74,p-value = 0.02), minimal-redundancy-maximal-relevance criterion (mRMR) (AUC = 0.73,p-value = 0.05), F-score (AUC = 0.48,p-value < 0.01), and mutual information (AUC = 0.69,p-value < 0.01) methods. Compared to single-objective methods, the AUC of MRMOPSO is 12% higher than those of the genetic algorithm (GA) (AUC = 0.68,p-value = 0.02) and particle swarm optimization algorithm (AUC = 0.72,p-value = 0.05) methods. Compared to other multi-objective feature selection methods, the AUC of MRMOPSO is 14% higher than those of multiple objective particle swarm optimization (MOPSO) (AUC = 0.68,p-value = 0.02) and nondominated sorting genetic algorithm II (NSGA2) (AUC = 0.70,p-value = 0.03).Significance.We proposed a multi-objective based radiomics feature selection method. Compared to conventional feature reduction algorithms, the proposed algorithm effectively reduced feature dimension, and achieved superior performance, with improved sensitivity and specificity, for response prediction in radiotherapy.