医学
前瞻性队列研究
2型糖尿病
危险系数
维生素D与神经学
混淆
队列研究
内科学
维生素D缺乏
队列
人口
四分位数
优势比
比例危险模型
糖尿病
环境卫生
置信区间
内分泌学
作者
Ana Valer-Martinez,Carmen Sayón-Orea,J. Alfredo Martínéz,Francisco Javier Basterra-Gortari,Miguel Ángel Martínez‐González,Maira Bes–Rastrollo
标识
DOI:10.1007/s40618-024-02324-3
摘要
Abstract Purpose Vitamin D deficiency has been associated with multiple chronic diseases, including metabolic disorders such as insulin resistance and type 2 diabetes (T2D). The aim of the study was to analyze the association between validated predicted serum vitamin D status and the risk of developing T2D in a large prospective cohort based on a Mediterranean population. Methods The SUN project is a prospective and dynamic Spanish cohort that gathers university graduates who have answered lifestyle questionnaires, including a validated Food Frequency Questionnaire. The association between predicted serum vitamin D and the risk of T2D was assessed through Cox regression models according to quartiles (Q) of predicted vitamin D at baseline. The models were adjusted for potential confounders and sensitivity analyses were performed to ensure the robustness of our findings. Results Our study included a total of 18,594 participants and after a total follow-up of 238,078 person-years (median follow-up of 13.5 years), 209 individuals were diagnosed with incident T2D. We found a significant inverse association between predicted levels of serum vitamin D and the risk of developing T2D, after adjusting for potential confounders and performing different sensitivity analyses (hazard ratio Q4 vs. Q1: 0.48, 95% CI 0.26–0.88; p for trend = 0.032). Conclusion The outcomes suggest that higher levels of vitamin D at baseline may be associated with a reduced risk of developing T2D.
科研通智能强力驱动
Strongly Powered by AbleSci AI