this study is done to understand the effectiveness of intra dialytic stretching exercises for relief of muscle cramps which is the common problem faced by the patients undergoing hemodialysis. The aim of the study to assess the effectiveness of muscle stretching exercise during intradialytic period and to associate the muscle cramps with selected demographic variables. Only post test control design was used with 120 samples (60 in each group). Simple random sampling was used to select the samples. The data was collected by interview method. The results revealed that Maximum of the participants had moderate level (80%) of muscle cramps in first 2 days and 3rd day they had mild cramp (70%)s in experimental group in which intra dialytic stretching exercise was administered. The statistical significant association was found with demographic variables and the level of muscles cramps score. More weight of fluid i.e. 3 - 4 liters shows highly significant (P=0.01) and constant patterns of muscle cramps also shows highly significant (P=0.01).Duration of dialysis i.e. < 3 months shows significant (P=0.05).