肠道菌群
普氏粪杆菌
结直肠癌
医学
拟杆菌
生物
瘤胃球菌
癌症
机制(生物学)
乳酸菌
双歧杆菌
真细菌
普雷沃菌属
微生物群
免疫学
微生物学
生物信息学
遗传学
细菌
哲学
认识论
作者
Hui Zhao,Min He,Meng Zhang,Qiang Sun,Shengkui Zeng,Li Chen,Han Yang,Maolun Liu,Shan Ren,Xianli Meng,Haibo Xu
标识
DOI:10.1142/s0192415x21500385
摘要
Based on the study and research on the pathogenesis of colorectal cancer, the types and functions of gut microbiota, and its role in guiding and regulating the occurrence and development of diseases, we have explored the mechanism of traditional Chinese medicine in the treatment of colorectal cancer by regulating the gut microbiota. Genetic variation, abnormal responses of innate and adaptive immunity, mucosal barrier dysfunction, imbalance of intestinal microbial colonization, personal and environmental risk factors are the main pathogenesis of colorectal cancer. The gut microbiota mainly includes Sclerotium (including Clostridium, Enterococcus, Lactobacillus and Ruminococcus) and Bacteroides (including Bacteroides and Prevotella), which have biological antagonism, nutrition for the organism, metabolic abilities, immune stimulation, and ability to shape cancer genes functions to body. The gut microbiota can be related to the health of the host. Current studies have shown that Chinese herbal compound, single medicinal materials, and monomer components can treat colorectal cancer by regulating the gut microbiota, such as Xiaoyaosan can increase the abundance of Bacteroides, Lactobacillus, and Proteus and decrease the abundance of Desulfovibrio and Rickerella. Therefore, studying the regulation and mechanism of gut microbiota on colorectal cancer is of great benefit to disease treatment.
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