Structural Basis for Heme Recognition by HmuT Responsible for Heme Transport to the Heme Transporter in Corynebacterium glutamicum

The crystal structure of HmuT from Corynebacterium glutamicum, which is a heme-binding protein in an ABC-type heme transporter system, HmuTUV, has been determined in the holo-form. Heme was accommodated with two different orientations in the central cleft, in which His141 and Tyr240 were coordinated to the heme as axial ligands.