ABI3 Is a Novel Early Biomarker of Alzheimer’s Disease

海马体 生物标志物 小胶质细胞 外周血单个核细胞 医学 阿尔茨海默病 内科学 认知功能衰退 脑脊液 内分泌学 病理 免疫学 疾病 生物 痴呆 遗传学 体外 炎症
作者
Min Cao,Jing Liu,Xiaomin Zhang,Tingting Yang,Yaqi Wang,Yuli Hou,Qiao Song,Yuting Cui,Yifei Wang,Peichang Wang
出处
期刊:Journal of Alzheimer's Disease [IOS Press]
卷期号:87 (1): 335-344 被引量:4
标识
DOI:10.3233/jad-215635
摘要

Background: The Abi3 gene has been suggested to be an important regulator of microglia during Alzheimer’s disease (AD), but the diagnostic power of ABI3 in neurodegenerative disease has rarely been reported. Objective: The aim of this study was to evaluate the diagnostic value of ABI3 in AD patients. Methods: ELISAs were used to measure the ABI3 level in the serum and cerebrospinal fluid (CSF) of AD patients as well as in the serum of APP/PS1 mice. RT-PCR and western blot were further performed to detect the expression levels of ABI3 in peripheral blood mononuclear cells (PBMCs) of AD subjects as well as in the hippocampus and cortical tissue of APP/PS1 mice. The correlation of cognitive ability with ABI3 level was estimated by linear regression analysis. Moreover, the diagnostic value of ABI3 for AD was assessed with ROC analysis. Results: The ABI3 levels all decreased significantly in the serum, CSF, and PBMCs of AD patients and showed a good diagnostic performance. In addition, the ABI3 levels were observed to decrease markedly in the hippocampus from 5-month-old mice, but the dramatic change only appeared in the cortical tissue in the 9-month-old APP/PS1 mice. The ABI3 levels in serum and in the hippocampus of APP/PS1 mice were significantly correlated with cognitive capacity. Conclusion: These results demonstrated that ABI3 in serum, CSF, and PBMCs could be a novel early diagnostic biomarker of AD. Moreover, ABI3 had potential to be a novel tracer marker in hippocampus of early AD.
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