透视图(图形)
受体
甘氨酸
缺血性损伤
内皮
医学
重症监护医学
药理学
缺血
心脏病学
氨基酸
生物化学
生物
内科学
人工智能
计算机科学
作者
Ricardo Valdés-Jorquera,Leticia Oviedo-Castro,Carolina A. Oliva,Trinidad Mariqueo
出处
期刊:Current Vascular Pharmacology
[Bentham Science]
日期:2022-03-01
卷期号:20 (3): 221-229
被引量:1
标识
DOI:10.2174/1570161120666220720101352
摘要
Glycine Receptors (GlyRs) are cell-surface transmembrane proteins that belong to the Cysloop ligand-gated ion channels superfamily (Cys-loop LGICs). Functional glycine receptors are conformed only by α-subunits (homomeric channels) or by α- and β-subunits (heteromeric channels). The role of glycine as a cytoprotective is widely studied. New information about glycine modulation of vascular endothelial cells (ECs) function emerged last year. Glycine and its receptors are recognized to play a role as neurovascular protectors by a mechanism that involves α2GlyRs. Interestingly, the expression of α2GlyRs reduces after stroke injury. However, glycine reverses the inhibition of α2GlyRs by a mechanism involving the VEGF/pSTAT3 signaling. On the other hand, consistent evidence has demonstrated that ECs participate actively in the innate and adaptive immunological response. We recently reported that GlyRs are modulated by interleukin-1β, suggesting new perspectives to explain the immune modulation of vascular function in pathological conditions such as cerebrovascular stroke. In this work, we distinguish the role of glycine and the allosteric modulation of glycine receptors as a new therapeutic target to confront post-ischemic injury.
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