转移
癌症研究
肺癌
原癌基因酪氨酸蛋白激酶Src
癌症
细胞生长
酪氨酸激酶
前列腺癌
医学
生物
内科学
肿瘤科
受体
遗传学
作者
Hongbing Liu,Ying Wu,Suhua Zhu,Wenjun Liang,Zhaofeng Wang,Yunfen Wang,Tangfeng Lv,Yanwen Yao,Dongmei Yuan,Yang Song
出处
期刊:Cancer Letters
[Elsevier]
日期:2015-04-01
卷期号:359 (2): 218-225
被引量:69
标识
DOI:10.1016/j.canlet.2015.01.020
摘要
Previous studies have demonstrated that protein tyrosine phosphatase 1B (PTP1B) can promote tumor progression in breast cancer, colon cancer and prostate cancer. Additionally, PTP1B acts as a tumor suppressor in other cancers, such as esophageal cancer and lymphoma. These findings suggest that PTP1B functions as a double-facet molecule in tumors, and the role of PTP1B in non-small cell lung cancer (NSCLC) is unknown. The present study demonstrates that the expression of PTP1B in NSCLC tissue is significantly higher than its expression in benign lung disease and is associated with the stage and overall survival (OS) of NSCLC patients. In vitro studies have demonstrated that PTP1B promotes the proliferation and metastasis of NSCLC cells by reducing the expression of p-src (Tyr527), which activates src and ERK1/2. This study provides the first exploration of the role of PTP1B in the proliferation and metastasis of NSCLC and subsequently elucidates the role of PTP1B in cancer. Our study uncovered that PTP1B can promote NSCLC proliferation and metastasis by activating src and subsequently ERK1/2 and provides a theoretical basis for future applications of PTP1B inhibitors in the treatment of NSCLC.
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