驱动蛋白
有丝分裂
微管
生物
运动蛋白
药物开发
药品
细胞生物学
药理学
作者
Oliver Rath,Frank Kozielski
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2012-08-01
卷期号:12 (8): 527-539
被引量:369
摘要
Kinesins are a family of molecular motors that travel unidirectionally along microtubule tracks to fulfil their many roles in intracellular transport or cell division. Over the past few years kinesins that are involved in mitosis have emerged as potential targets for cancer drug development. Several compounds that inhibit two mitotic kinesins (EG5 (also known as KIF11) and centromere-associated protein E (CENPE)) have entered Phase I and II clinical trials either as monotherapies or in combination with other drugs. Additional mitotic kinesins are currently being validated as drug targets, raising the possibility that the range of kinesin-based drug targets may expand in the future.
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