纤维发生
再生医学
生物相容性
胶原纤维
整合素
细胞外基质
材料科学
组织工程
纳米技术
纤维
生物物理学
生物医学工程
化学
生物化学
解剖
工程类
生物
细胞
冶金
作者
Kendell M. Pawelec,Serena M. Best,Ruth E. Cameron
摘要
The basic building block of the extra-cellular matrix in native tissue is collagen. As a structural protein, collagen has an inherent biocompatibility making it an ideal material for regenerative medicine. Cellular response, mediated by integrins, is dictated by the structure and chemistry of the collagen fibers. Fiber formation, via fibrillogenesis, can be controlled in vitro by several factors: pH, ionic strength, and collagen structure. After formation, fibers are stabilized via cross-linking. The final bioactivity of collagen scaffolds is a result of both processes. By considering each step of fabrication, scaffolds can be tailored for the specific needs of each tissue, improving their therapeutic potential.
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