Antifungal, Ergosterol Synthesis Inhibitors (Conazoles)

Invasive infections with fungi are continuing to increase and cause significant morbidity and mortality. The azole family of antifungal agents has indications for many fungal pathogens. They have few adverse effects compared with amphotericin B. The triazole family has mostly replaced the use of early azoles, such as ketoconazole, due to improved safety and efficacy. Each of the five members of the triazole family (fluconazole, voriconazole, itraconazole, posaconazole, and isavuconazole) has different characteristics that prove each one effective for specific cases. Ketoconazole is a common topical antifungal for cutaneous fungal infections, including cutaneous candidiasis, seborrheic dermatitis, tinea infections, and dandruff.