单线态氧
化学
光动力疗法
光敏剂
卟啉
二芳基乙烯
光化学
部分
共价键
原卟啉IX
组合化学
纳米技术
光致变色
有机化学
氧气
材料科学
作者
Hong Cheng,Bin Qiao,Hao Li,Jin Cao,Yuanli Luo,K. M.K. Swamy,Jing Zhao,Zhigang Wang,Jin Yong Lee,Xing Lü,Juyoung Yoon
摘要
The development of activatable photosensitizers to allow for the reversible control of singlet oxygen (1O2) production for photodynamic therapy (PDT) faces great challenges. Fortunately, the flourishing field of supramolecular biotechnology provides more effective strategies for activatable PDT systems. Here, we developed a new reversible PDT on a switch that controls the 1O2 generation of self-assembled albumin nanotheranostics in vitro and in vivo. A new molecular design principle of aggregation-induced self-quenching photochromism and albumin on-photoswitching was demonstrated using a new asymmetric, synthetic diarylethene moiety DIA. The photosensitizer porphyrin and DIA were incorporated as building blocks in a glutaraldehyde-induced covalent albumin cross-linking nanoplatform, HSA–DIA–porphyrin nanoparticles (NPs). More importantly, the excellent photoswitching property of DIA enables the resultant nanoplatform to act as a facile, switchable strategy for photodynamic-immunotherapy.
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