Biointegrated Implantable Brain Devices

Implantable neural devices are the most widely applied tools in neuroscience research as well as neuroprosthetics to record neural signal activities at single-neuron and sub-millisecond resolution. However, lack of mechanical compatibility between the traditional rigid probes and brain tissues causes neuroinflammatory responses and deteriorate recorded signal quality. Decreasing the cross-sectional area while improving flexibility of the probes can significantly enhance the chronic stability of neural interfaces. Additionally, magnetic resonance imaging (MRI) compatibility is another issue that should be addressed for the development of future implantable devices. Herein, current advancement in developing the chronically stable implantable neural devices is highlighted, with a emphasis on making use of the sophisticated materials and structural design concepts.