神经营养因子
神经营养素
神经生长因子
神经科学
维生素D与神经学
侧脑室
内分泌学
内科学
皮质(解剖学)
维生素
大脑发育
脑源性神经营养因子
大脑皮层
生物
受体
心理学
医学
作者
Darryl W. Eyles,Jillanne Brown,Alan Mackay‐Sim,John J. McGrath,François Féron
出处
期刊:Neuroscience
[Elsevier]
日期:2003-05-01
卷期号:118 (3): 641-653
被引量:484
标识
DOI:10.1016/s0306-4522(03)00040-x
摘要
Evidence for the presence of the vitamin D receptor in brain implies this vitamin may have some function in this organ. This study investigates whether vitamin D(3) acts during brain development. We demonstrate that rats born to vitamin D(3)-deficient mothers had profound alterations in the brain at birth. The cortex was longer but not wider, the lateral ventricles were enlarged, the cortex was proportionally thinner and there was more cell proliferation throughout the brain. There were reductions in brain content of nerve growth factor and glial cell line-derived neurotrophic factor and reduced expression of p75(NTR), the low-affinity neurotrophin receptor. Our findings would suggest that low maternal vitamin D(3) has important ramifications for the developing brain.
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