Detection rate of 99mTc‐MIBI single photon emission computed tomography (SPECT)/CT in preoperative planning for patients with primary hyperparathyroidism: A meta‐analysis

abstract Background Parathyroid scintigraphy using 99m Tc‐MIBI single photon emission computed tomography (SPECT)/CT has been proposed as one of the most accurate localization techniques in patients with primary hyperparathyroidism (PHPT). The purpose of this review was to meta‐analyze published data on the detection rate of 99m Tc‐MIBI SPECT/CT in the preoperative planning of patients with PHPT. Methods A comprehensive literature search of studies published through June 2014 was performed. The pooled detection rate of this scintigraphic method including 95% confidence intervals (95% CIs) was calculated on a per patient‐based and on a per lesion‐based analysis by using a random effects model. Results Twenty‐three articles including 1236 patients with PHPT were selected. The pooled detection rate of 99m Tc‐MIBI SPECT/CT in the preoperative planning of patients with PHPT was 88% (95% CI = 84% to 92%) and 88% (95% CI = 82% to 92%) on a per patient‐based and per lesion‐based analysis, respectively. Conclusion The 99m Tc‐MIBI SPECT/CT has high detection rate for hyperfunctioning parathyroid glands in patients with PHPT. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E2159–E2172, 2016