自噬
抗原处理
抗原呈递
生物
介绍(产科)
抗原
交叉展示
细胞生物学
免疫学
计算生物学
遗传学
免疫系统
医学
T细胞
细胞凋亡
放射科
作者
Rafael J. Argüello,Marisa Reverendo,Evelina Gatti,Philippe Pierre
摘要
Summary Antigenic peptides presented in the context of major histocompatibility complex ( MHC ) molecules originate from the degradation of both self and non‐self proteins. T cells can therefore recognize at the surface of surveyed cells, the self‐peptidome produced by the cell itself (mostly inducing tolerance) or immunogenic peptides derived from exogenous origins. The initiation of adaptive immune responses by dendritic cells ( DC s), through the antigenic priming of naïve T cells, is associated to microbial pattern recognition receptors engagement. Activation of DC s by microbial product or inflammatory cytokines initiates multiple processes that maximize DC capacity to present exogenous antigens and stimulate T cells by affecting major metabolic and membrane traffic pathways. These include the modulation of protein synthesis, the regulation of MHC and co‐stimulatory molecules transport, as well as the regulation of autophagy, that, all together promote exogenous antigen presentation while limiting the display of self‐antigens by MHC molecules.
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