Phase II clinical study of S(+)-ismer of ibuprofen on rheumatoid arthritis and osteoarthritis patients

[Objective] To investigate the effect and safty of S(+)-ismer of ibuprofen on RA and OA patients. [Method] In this randomized multi-center, double-blind, control study, those patient with RA and OA received a single dose of either S(+)-ismer of ibuprofen (0.4~0.6 g, bid) or ibuprofen (0.4~0.6 g, bid) for four weeks. [Result] Besides the total effective rate and the total improvable rate, tender joint and swollen joint had been improved significantly, compared with ibuprofen treatment group. There was no difference in side-effects between the two groups. [Conclusion] Like ibuprofen, S(+)-ismer of ibuprofen is effective, but its adverse-effects are less than ibuprofen.