Studies on Changes in Rations of High Molecuar Fatty Acid Composition, Constituting Hepatic Lipids in Irradiated Animals

After giving whole-body irradiation of 600R, albumin complexed-palmitic acid-1-14C or linoleic acid-14C were used to mice, and we studied differences in changes of metabolism in these irradiated animals. For this study we measured amounts of 14CO2 exhaled, specific activity of liver lipids, and activities of individual fatty acid fractions with lapse of time, and obtained the following results.1) It was found that the incorporation of palmitic acid-1-14C into 14CO2 was increased about 150% in the irradiated group as compared with that in controls. In contrast, that of linoleic acid-1-14C was decreased by about 50% as compared with controls.2) The incorporation of palmitic acid-1-14C into liver lipids was considerable in the early stage after the the irradiation, but it decreased rapidly and became less than that of controls wi thin a short period of time. The uptake of linoleic acid-1-14C into the liver of inadiated qroup was found to have been decreased.3) In the irradiated groups, data revealed an inhibitory effect on unsaturation and chain el ongation of both palmitic acid and linoleic acid.