生长抑素
下丘脑
生长抑素受体
神经肽
内科学
内分泌学
纹状体
受体
生物
神经递质
中枢神经系统
共域化
壳核
尾状核
化学
神经科学
医学
多巴胺
作者
Philippe Leroux,Georges Pelletier
出处
期刊:Peptides
[Elsevier]
日期:1984-05-01
卷期号:5 (3): 503-506
被引量:54
标识
DOI:10.1016/0196-9781(84)90078-0
摘要
Somatostatin-14 (S14) and its precursor, somatostatin-28 (S28), are widely distributed throughout the rat brain, suggesting that they could act as neurotransmitter or neuromodulator in the central nervous system. The present study was undertaken to study the localization of S14 and S28 receptors in the rat brain determined by “in vitro” radioautography. The study performed on slide mounted frozen brain section with iodinated S14 and S28 analogs revealed an identical distribution of binding sites for the two forms of somatostatin. A good correlation could be observed between receptor distribution and immunohistologically localized neuropeptides except for striatum and hypothalamus. However, receptors were not detectable in the hypothalamus and were found in low concentration in the caudate-putamen nucleus, two regions containing high amounts of S28 and S14, suggesting a high occupancy of receptors in these areas by endogenous peptides or an inverse correlation between receptor and peptide concentrations.
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