Peptidomimetics and Peptide Backbone Modifications

The replacement of the amide bond in a peptide backbone is a widely used form of peptide mimicry. Several of the most common amide bond surrogates, including peptidomimetic work done in this laboratory, and their biological applications are presented in this review. Keywords: peptidomimetics, backbone modifications, hydrophobicity of pseudopeptides, enzymatic stability, amino acids, human, immunodeficiency