Syntheses of armed‐macrocycles by reductive amination using NaBH(OAc)3 under 1 MPa

Abstract magnified image Armed‐monoaza‐12‐crown‐4, monoaza‐15‐crown‐5, diaza‐12‐crown‐4, diaza‐18‐crown‐6 ethers, and 1,4,7,10‐tetraazacyclododecane having aromatic pendants were prepared by the reductive amination of the corresponding macrocycles with aromatic carboxyaldehydes in the presence of NaBH(OAc) 3 . Reductive amination under 1 MPa conditions provided significant shortening of the reaction time and yield enhancements.