分子成像
癌症手术
荧光寿命成像显微镜
生物医学工程
光学成像
癌症
肿瘤微环境
医学影像学
癌症检测
影像引导手术
材料科学
病理
荧光
癌症研究
放射科
医学
肿瘤细胞
生物
体内
光学
内科学
物理
生物技术
作者
Chensu Wang,Zhaohui Wang,Tian Zhao,Yang Li,Gang Huang,Baran D. Sumer,Jinming Gao
出处
期刊:Biomaterials
[Elsevier]
日期:2018-03-01
卷期号:157: 62-75
被引量:175
标识
DOI:10.1016/j.biomaterials.2017.12.002
摘要
We have witnessed rapid development of fluorescence molecular imaging of solid tumors for cancer diagnosis and image-guided surgery in the past decade. Many biomarkers unique to cancer cells or tumor microenvironment, such as cell surface receptors, hypoxia, secreted proteases and extracellular acidosis have been characterized, and can be used to distinguish cancer from normal tissue. A variety of optical imaging probes have been developed to target these biomarkers to improve tumor contrast over the background tissue. Unlike conventional anatomical and molecular imaging technologies, fluorescent imaging method benefits from its safety, high-spatial resolution and real-time capability, and therefore, has become a highly adoptable imaging method for tumor detection and image-guided surgery in clinics. In this review, we summarize recent progress in 'always-ON' and stimuli-activatable fluorescent imaging probes, and discuss their potentials in tumor detection and image-guided surgery.
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