Objective: To evaluate quality of National Demonstration Area for Comprehensive Prevention and Control of NCDs (referred to as the Demonstration Area). Methods: Based on evaluation scores of Demonstration Area field survey from 2017 to 2019, we counted scores of each indicator, comparing scores among indicators and regions. x±s was used to describe scores. The 95%CI of score was used to test statistical difference among regions. Each score was converted into a hundred-mark system to compare scores among indicators. Results: Of 236 Demonstration Areas, total score was 83.5. The scores of first-level indicator listed from high to low appeared as Integrating System of NCD Prevention and Control (92.8), Policy Perfection (90.3), Building Supportive Environment for NCD Prevention and Control (88.4), Implementation of Health Education and Health Promotion (87.4), Whole-course Management of NCDs (78.1), Innovation and Guidance (76.5), Surveillance and Evaluation (75.1). Total scores were higher in east (259.2±18.8) comparing to middle (243.2±15.2) or west (245.4±19.7) regions. Conclusions: Substantial variations on quality in Demonstration Area existed across different regions in China. These disparities are important to government when developing health policies and allocating resources. Whole-course Management of NCDs, Surveillance and Evaluation, and Innovation and Guidance in Demonstration Area also needs to be improved.