活性氧
材料科学
细胞内
光催化
纳米片
超氧化物
谷胱甘肽
癌细胞
生物物理学
光化学
辐照
体内
催化作用
纳米技术
化学
癌症
生物化学
生物
物理
生物技术
核物理学
遗传学
酶
作者
Yong Kang,Lei Lei,Chunfeng Zhu,Hanjie Zhang,Lin Mei,Xiaoyuan Ji
出处
期刊:Materials horizons
[The Royal Society of Chemistry]
日期:2021-01-01
卷期号:8 (8): 2273-2285
被引量:40
摘要
A piezo-photocatalytic therapy based on thermally treated natural sphalerite nanosheet (NSH700 NS) heterojunction was applied to efficiently induce intracellular ROS burst and apoptosis of cancer cells. Upon ultrasound and laser irradiation, the formation of a polarized electric field and band bending of NSH700 NSs allow the directional separation of charges both in the bulk and their interface, thereby minimizing the probability of charge recombination. The piezo-photocatalytic effect leads to an efficient catalytic performance, exhibiting high-performance superoxide radical (˙O2-) and hydroxyl radical (˙OH) generation and glutathione (GSH) depletion, which results in a intracellular ROS burst-triggered apoptosis of cancer cells both in vitro and in vivo.
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