糖基化
聚糖
生物
生物合成
机制(生物学)
N-连接糖基化
计算生物学
疾病
翻译(生物学)
细胞生物学
生物化学
基因
化学
糖蛋白
信使核糖核酸
医学
哲学
病理
认识论
作者
Ana Magalhães,Hugo Duarte,Celso A. Reis
标识
DOI:10.1016/j.mam.2021.100964
摘要
O-glycosylation is a highly frequent post-translation modification of proteins, with important functional implications in both physiological and disease contexts. The biosynthesis of O-glycans depends on several layers of regulation of the cellular glycosylation machinery, being organ-, tissue- and cell-specific. This review provides insights on the molecular mechanism underlying O-glycan biosynthesis and modification, and highlights illustrative examples of diseases that are triggered or modulated by aberrant cellular O-glycosylation. Particular relevance is given to genetic disorders of glycosylation, infectious diseases and cancer. Finally, we address the potential of O-glycans and their biosynthetic pathways as targets for novel therapeutic strategies.
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