托法替尼
医学
溃疡性结肠炎
药代动力学
贾纳斯激酶
药效学
药理学
药品
Janus激酶抑制剂
内科学
炎症性肠病
胃肠病学
细胞因子
疾病
类风湿性关节炎
作者
Bram Verstockt,Dahham Alsoud,Joep van Oostrom,Sare Verstockt,Jeff Smith,Jack Stylli,Sujay Singh,Sara van Gennep,Pejman Rahimian,João Sabino,Marc Ferrante,Ariella Kelman,Sharat Singh,Geert D’Haens,Séverine Vermeire
标识
DOI：10.1093/ecco-jcc/jjaf063
摘要
This study underscores the importance of tissue tofacitinib levels in UC treatment efficacy, with pSTAT3 reduction serving as a potential marker of drug efficacy. RNA sequencing identified molecular pathways for potential biomarkers and novel therapeutic targets in tofacitinib non-responders.
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(2025-6-4)
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