Regiodivergent and Enantioselective Hydroboration of Dienol Ethers

catalyst and chiral ligands. The reaction exhibits good functional group compatibility and broad substrate scope, selectively affording 1,2-, 4,1-, 1,4-, and 4,3-hydroboration products in good yields and high regio- and enantioselectivities (up to >99%). Mechanistic studies, including deuterium-labeling, kinetic, and UV-vis experiments, suggest the involvement of Co-H species as active catalysts in the reactions. The powerful conversion capabilities of the products are demonstrated by various downstream transformations and the efficient preparation and late-stage elaboration of bioactive compounds.