Luminescent Ln-MOFs for Chemical Sensing Application on Biomolecules

At present, the application of rare-earth organic frameworks (Ln-MOFs) in fluorescence sensing has entered rapid development and shown great potential in various analytical fields, such as environmental analysis, food analysis, drug analysis, and biological and clinical analysis by utilizing their internal porosity, tunable structural size, and energy transfer between rare-earth ions, ligands, and photosensitizer molecules. In addition, because the luminescence properties of rare-earth ions are highly dependent on the structural details of the coordination environment surrounding the rare-earth ions, and although their excitation lifetimes are long, they are usually not burst by oxygen and can provide an effective platform for chemical sensing. In order to further promote the development of fluorescence sensing technology based on Ln-MOFs, we summarize and review in detail the latest progress of the construction of Ln-MOF materials for fluorescence sensing applications and related sensor components, including design strategies, preparation methods, and modification considerations and initially propose the future development prospects and prospects.