内皮
细胞生物学
生物
鼻病毒
血管内皮生长因子
肺
免疫学
血管内皮生长因子B
血管内皮生长因子A
医学
病毒
癌症研究
内分泌学
内科学
血管内皮生长因子受体
作者
Aleksandra Likońska,Mateusz Gawrysiak,Adrian Gajewski,Kinga Klimczak,Sylwia Michlewska,Robert Szewczyk,Izabela Gulbas,Maciej Chałubiński
出处
期刊:Apmis
[Wiley]
日期:2022-08-26
卷期号:130 (11): 678-685
被引量:3
摘要
Vascular endothelium is a semi‐permeable barrier that regulates the flow of nutrients, ions, cytokines and immune cells between blood and tissues. Barrier properties of endothelium, its ability to regenerate and the potential for secretion of inflammatory mediators play a crucial role in maintaining local tissue homeostasis. The lung vascular endothelial cells were shown to be infected by human rhinovirus (HRV) and generate antiviral, inflammatory and cytopathic responses. The current study reveals that in the long‐time manner, the lung vascular endothelium may efficiently limit the HRV replication via the IFN‐dependent 2′‐5′‐oligoadenylate synthetase 1 activation. This leads to the restoration of integrity accompanied by the up‐regulation of adherens and tight junctions, increase of metabolic activity and proliferation rate. Secondly, HRV16‐infected cells show delayed and transient up‐regulation of the expression of vascular endothelial growth factor (VEGF), fibroblast growth factor, angiopoietin 1 and 2, and neuropilin‐1, as well as VEGF receptors. The lung vascular endothelium infected with HRV may limit the infection, recover in time, and regain barrier properties and metabolic functions, thus leading to the restoration of integrated barrier tissue.
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