Human health risks estimations from Liquid crystal monomers（LCMs）in Northwest China : partitioning, clearance and exposure in paired human serum and urine

Mobile phones, televisions, computers and other liquid crystal devices have become the electronic products widely used by humans in modern society. Liquid crystal monomers (LCMs) are the key material of liquid crystal display and considered as potential persistent, bioaccumulative, and toxic (PBT) substances in recent years, but there is a limited of information regarding their occurrence in human body. We used EPI suite software from USEPA to evaluate its physical and chemical properties, analyzed its concentration in serum and urine by GC-MS, and finally assessed its health risk to humans through the calculation of daily intake. In this paper, 15 LCMs were detected in serum and urine samples of the general population, with median concentrations ranging from 9.7 to 124.8 and 2.68 to 36.98 µg/L, respectively. The correlation of LCM in serum and urine suggests that they have potential common applications and similar sources. The results showed that the CLrenal of LCMs in the Northwest China population was 0.61, 7.79, 6.04, 4.81, 9.37, 4.85, 19.94, 10.64, 3.80, 7.44, 8.26, 15.39, 7.52, 10.17, 13.54 mL/kg/day for EBCN, BCBP, PBIPHCN, DFPrB, FPrCB, BEEB, BMBC, DFPCB, DFEEB, EPrCPB, EEPrTP, EDFPB, DFPrPrCB, EFPeT, TeFPrT, respectively. The daily intake for ∑LCMs in the adult of northwest China was 22.35 ng/kg bw/day, indicating a potential exposure risk to the general population. This study provides the first evidence for the presence of LCM in serum and urine in the daily population and finds a correlation between LCMs, but the differences in B/U ratio and renal clearance indicate the need for further investigation of its metabolism and clearance in the human body.