Effects of transcutaneous electrical diaphragmatic stimulation in critically ill elderly patients: a randomized controlled trial

ABSTRACTBackground Elderly patients under invasive mechanical ventilation (IMV) are more susceptible to muscle weakness. In the out-of-hospital environment, there are benefits to transcutaneous electrical diaphragmatic stimulation (TEDS), which is an easy-to-apply and low-cost technique.Objective To evaluate the effect of TEDS on respiratory muscle strength, diaphragm thickness (DT), and IMV time in critically ill elderly patients.Methods This was a randomized controlled trial in which patients were divided into an experimental group (EG) and a control group (CG). TEDS started 24 h after orotracheal intubation and lasted until the end of weaning. Both groups underwent the following assessments during the spontaneous breathing test after weaning from mechanical ventilation (MV): measurement of respiratory muscle strength by pressure gauge, analysis of DT by lung ultrasound, and extubation failure prevention checklist.Results There were 23 participants in the EG and 21 in the CG. The median age was 66 (60–79) years. The mean values of the diaphragmatic thickening index in the EG and CG participants were 99.13 ± 26.75 and 66.88 ± 31.77, respectively (p = .001, Cohen’s d = 1.094). The mean values of maximum inspiratory pressure in the EG and CG were 22.04 ± 3.41 and 19.34 ± 4.23 cmH2O, respectively (p = .005, Cohen’s d = 0.698). The Tobin index and the integrative weaning index were similar between groups (p = .584 and p = .102, respectively). The duration of MV in the EG and CG was 6.28 ± 2.68 and 9.21 ± 2.76 days, respectively (p = .001, Cohen’s d = -1.075).Conclusion Critically ill elderly patients receiving TEDS had shorter MV time, greater inspiratory muscle strength, and greater diaphragmatic contraction capacity according to their thickness fraction.KEYWORDS: Agingintensive carepulmonary rehabilitationmusculoskeletal AcknowledgmentsThis work was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnólogico (CNPq) under Grant number #301967/2022-9, Brazil, the Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) under Grant numbers #E-26/010.002124/2019, #E-26/211.187/2021, #E-26/211.104/2021, and #E-26/200.929/2022, Brazil, and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) under Grant numbers FinanceCode 001, 88881.708719/2022-01, and 88887.708718/2022-00.Disclosure statementNo potential conflict of interest was reported by the author(s).Additional informationFundingThe work was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico [#301967/2022-9]; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior [FinanceCode 001, 88881.708719/2022-01, 88887.708718/2022-00]; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro [#E-26/010.002124/2019, #E-26/211.187/2021, #E-26/211.104/2021, #E-26/200.929/2022].