阿玛林
立体化学
化学
分子内力
圆二色性
夹竹桃科
戒指(化学)
生物碱
生物
有机化学
植物
神经科学
作者
Ziwei Li,Chun‐Lin Fan,Bo Sun,Lan Huang,Ziqi Wang,Xiao‐Jun Huang,Shi-Qin Zhang,Wen‐Cai Ye,Zhen‐Long Wu,Xiaoqi Zhang
标识
DOI:10.1002/chem.202303519
摘要
Three unusual ajmaline-macroline type bisindole alkaloids, alsmaphylines A-C, together with their postulated biogenetic precursors, were isolated from the stem barks and leaves of Alstonia macrophylla via the building blocks-based molecular network (BBMN) strategy. Alsmaphyline A represents a rare ajmaline-macroline type bisindole alkaloid with an S-shape polycyclic ring system. Alsmaphylines B and C are two novel ajmaline-macroline type bisindole alkaloids with N-1-C-21' linkages, and the former possesses an unconventional stacked conformation due to the presence of intramolecular noncovalent interactions. The chemical structures including absolute configurations of alsmaphylines A-C were established by comprehensive spectroscopic analyses, electronic circular dichroism (ECD) calculations, and single-crystal X-ray crystallography. In addition, a plausible biosynthetic pathway of these bisindole alkaloids as well as their ability to promote the protein synthesis on HT22 cells were discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI