MYH6
Cre重组酶
生殖系
转基因
生物
重组酶
位点特异性重组
分子生物学
体细胞
基因
遗传学
转基因小鼠
细胞生物学
重组
基因亚型
MYH7
作者
Caroline Sheldon,Chase W. Kessinger,Yan Sun,Maria I. Kontaridis,Qianyi Ma,Saher Sue Hammoud,Zibei Gao,Hui Zhang,Zhiqiang Lin
标识
DOI:10.1016/j.yjmcc.2022.12.005
摘要
Myh6-Cre transgenic mouse line was known to express Cre recombinase only in the heart. Nevertheless, during breeding Myh6-Cre to Rosa26fstdTom reporter (tdTom) mouse line, we observed that a significant part of their F2 tdTom/+ offspring had tdTom reporter gene universally activated. Our results show that Myh6-Cre transgenic mice have Cre recombinase activity in a subpopulation of the male germline cells, and that Myh6 gene transcripts are enriched in the interstitial Leydig cells and the undifferentiated spermatogonia stem cells. In summary, the current study confirms that the previously known "heart-specific" Myh6 promoter drives Cre expression in the testis.
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