化学
羰基化
废止
催化作用
钯
对映选择合成
组合化学
有机化学
级联
路易斯酸
一氧化碳
色谱法
作者
Weiwei Ding,Yu Zhou,Zhi‐Yong Han,Liu‐Zhu Gong
标识
DOI:10.1021/acs.joc.2c02208
摘要
A highly enantioselective cascade carbonylation/annulation of benzyl bromides, CO, and vinyl benzoxazinanones under mild conditions has been established by Pd/chiral Lewis base relay catalysis, providing an efficient method to assemble chiral quinolinones from readily available starting materials in good yields with excellent diastereo- and enantioselectivities. The palladium catalyst plays two roles in this reaction, enabling both the carbonylation process and the generation of the zwitterionic π-allyl palladium intermediate.
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