Integrated 16S rRNA Sequencing and Untargeted Metabolomics Analysis to Revealthe Protective Mechanisms of Polygonatum sibiricum Polysaccharide on Type 2 DiabetesMellitus Model Rats

Our research revealed the therapeutic, anti-inflammatory and anti-oxidative effects of PSP on T2DM. The mechanisms of PSP on T2DM are associated with improving the dysbiosis of gut microbiota and regulating arginine and proline metabolism, tryptophan metabolism, and glutathione metabolism in serum.