亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

MiRNA-92a-3p mediated the association between occupational noise exposure and blood pressure among Chinese adults

血压 医学 置信区间 内科学 氧化应激 噪音(视频) 职业暴露 噪声暴露 联想(心理学) 心脏病学 听力学 环境卫生 听力损失 心理学 人工智能 计算机科学 图像(数学) 心理治疗师
作者
Wenzhen Li,Haozhe Zhang,Zhaomin Chen,Yueqing Tao,Xuezan Huang,Weihong Chen,Dongming Wang
出处
期刊:Science of The Total Environment [Elsevier]
卷期号:907: 168148-168148 被引量:2
标识
DOI:10.1016/j.scitotenv.2023.168148
摘要

Evidence on the association between occupational noise exposure and blood pressure is inconsistent, and the underlying mechanism remains unknown. This study aimed to evaluate the association between occupational noise exposure and blood pressure, and explore the potential role of miRNAs in the association. A total of 894 subjects from two companies in Wuhan, China were included. Occupational noise exposure was assessed using cumulative noise exposure (CNE), and six candidate plasma miRNAs (miR-92a-3p, miR-21-5p, miR-200a-3p, miR-200b-3p, miR-200c-3p, and miR-1-3p) which were not only associated with blood pressure/hypertension but also related to oxidative stress were selected according to previous studies and tested. A linear dose-response relationship was found between occupational noise exposure and blood pressure, including systolic blood pressure (SBP) and diastolic blood pressure (DBP). Each 1-unit increase in CNE levels was significantly associated with a 0.130 (95 % confidence interval [CI] = 0.026, 0.234) unit increase in SBP and a 0.141 (95 % CI = 0.063, 0.219) unit increase in DBP. However, the association between occupational noise and hypertension is not statistically significant (P > 0.05). In the meanwhile, occupational noise exposure was negatively associated with miRNA-92a-3p (β = -0.019, 95 % CI = -0.032, -0.006) and miRNA-21-5p (β = -0.031, 95 % CI = -0.052, -0.010), and miRNA-92a-3p mediated 24.66 % of the association between occupational noise exposure and DBP. In addition, bilateral high-frequency hearing loss was not only positively associated with occupational noise exposure (OR = 1.974, 95 % CI = 1.084, 3.702) but also DBP (β = 2.546, 95 % CI = 0.160, 4.932). Our study suggests that occupational noise exposure is positively associated with SBP and DBP, and miRNA-92a-3p partially mediate the association between occupational noise exposure and DBP.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
6秒前
16秒前
Billy完成签到,获得积分10
16秒前
Raina完成签到,获得积分10
32秒前
J-R完成签到 ,获得积分10
34秒前
程小柒完成签到 ,获得积分10
39秒前
上官若男应助咸鱼的艺术采纳,获得10
49秒前
Raina发布了新的文献求助10
50秒前
wxl完成签到,获得积分10
52秒前
rocky15应助清爽幼枫采纳,获得10
53秒前
shenlee发布了新的文献求助10
1分钟前
rocky15应助Huang采纳,获得10
1分钟前
1分钟前
1分钟前
phentjn发布了新的文献求助30
1分钟前
1分钟前
1分钟前
2分钟前
2分钟前
顾矜应助章访曼采纳,获得10
2分钟前
2分钟前
壮观的谷冬完成签到 ,获得积分10
2分钟前
清爽幼枫发布了新的文献求助10
2分钟前
嗯嗯嗯完成签到 ,获得积分10
2分钟前
托丽莲睡拿完成签到,获得积分10
3分钟前
一口蛋黄酥完成签到 ,获得积分10
3分钟前
Shandongdaxiu完成签到 ,获得积分10
3分钟前
3分钟前
Huang发布了新的文献求助10
3分钟前
3分钟前
章访曼发布了新的文献求助10
4分钟前
章访曼完成签到,获得积分10
4分钟前
汉堡包应助科研通管家采纳,获得10
4分钟前
Akim应助immm采纳,获得10
4分钟前
winkyyang完成签到 ,获得积分10
4分钟前
August完成签到,获得积分10
4分钟前
惜寒完成签到 ,获得积分10
4分钟前
ala完成签到,获得积分10
4分钟前
5分钟前
淡定树叶完成签到 ,获得积分10
5分钟前
高分求助中
Un calendrier babylonien des travaux, des signes et des mois: Séries iqqur îpuš 1036
Sustainable Land Management: Strategies to Cope with the Marginalisation of Agriculture 1000
Corrosion and Oxygen Control 600
Heterocyclic Stilbene and Bibenzyl Derivatives in Liverworts: Distribution, Structures, Total Synthesis and Biological Activity 500
重庆市新能源汽车产业大数据招商指南(两链两图两池两库两平台两清单两报告) 400
Division and square root. Digit-recurrence algorithms and implementations 400
行動データの計算論モデリング 強化学習モデルを例として 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2545380
求助须知:如何正确求助?哪些是违规求助? 2175631
关于积分的说明 5600155
捐赠科研通 1896323
什么是DOI,文献DOI怎么找? 946218
版权声明 565334
科研通“疑难数据库(出版商)”最低求助积分说明 503552