Objective:To investigate the effect of different dressing changes of Layers adjusting external application therapy on pain of acute soft tissue injury of ankle joint.Methods:A total of 40 acute soft tissue injury of ankle joint patients were assigned into the group with dressing change every day(A group) and the group with dressing change every 3 days(B group) for 7 days,20 in each group.The effect on pain in the two groups were recorded.Results:The effect in A group was low than B group(P0.05).Conclusion:Layers adjusting external application therapy with dressing change every day was proved to be more effective than dressing change every 3 days on treating acute soft tissue injury of ankle joint.